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Prontosan Wound Irrigation Solutions & Gels


Introducing the No Rinse Influence

We’re excited to introduce The No Rinse Influence™, which is for infected & non-infected wounds and inhibits bacteria growth within the product & provides debridement.

Various irrigation solutions require a thorough saline rinse after limited contact time halting the effect they may have. With Prontosan®, The No Rinse Influence enhances the experience and prolongs activity with no limit on contact time or application frequency for non-infected and infected wounds.

This product is safe, effective, requires no rinse, and is approved AND available at your facility. 


Two Powerful Active Ingredients: Betaine + Polyhexanide (PHMB)

  • Surfactants help to prevent bacteria from attaching to a surface aiding in the prevention of bacterial colonization & eventual biofilm formation.
  • Surfactants can break open existing biofilms exposing the underlying bacteria making them susceptible to external threat.
  • PHMB has multiple complex modes-of-action
  • PHMB remains stable and is not impaired
    under organic load, i.e. blood, proteins etc..
  • Binds to tissue for a remnant effect.
  • Strong safety profile with no cytotoxicity to
    the host tissue.
  • No Rinse Solution extending the mode-of-action of Prontosan for a long lasting effect.


How a local orthopedic surgeon is using The No Rinse Influence™

Total joint replacement is the most commonly performed elective surgery in the United States, with well over one million procedures performed annually. Hip replacement is projected to grow 171% and knee replacement by up to 189% by the year 2030.

This adds to the already significant revision hip and knee replacement burden which already plagues the healthcare system today. The average cost for a revision TKA in the United States is estimated at $75,028.07. With prosthetic joint infection costs skyrocketing to as high as six times the amount of a primary or revision arthroplasty.

In addition, revision surgery has been reported to have an infection rate that can exceed 10%. The overall cost to the American healthcare system has been estimated to reach as high as $1.62 billion in 2020.

With infection and postoperative wound complications being among the most common causes for revision hip and knee replacement in the United States we must focus considerable efforts toward prevention rather than treatment of these conditions.


Why Antiseptics? 

Antiseptics used in surgery are often based on anecdotal information and experience. In evaluating antiseptic options for orthopedic procedures, the ideal antiseptic would be one that is cost effective, have a rapid onset, non-toxic to human cells, effective in decreasing CFU’s across a broad spectrum of bacterial species, effective against bacterial recolonization, stable when exposed to blood and bodily proteins, be effective in the breakdown of existing biofilms, decreases post-operative pain, accelerates wound healing, does not have known bacterial resistance and has a low side effect profile.

In review of the current medical literature Prontosan is one of the only antiseptic agents that is effective in the above-mentioned criteria. PHMB has rapidly become the most frequently used antiseptic in orthopedic surgery.

PHMB may be one of the best eligible antiseptics for treatment of septic joints and cleansing the wound with PHMB prior to skin closure has been found to reduce the rate of SSI.


Whitepapers

Whitepaper: PHMB on Implants

While titanium implants are becoming more popular in clinical practice the prevalence of infections associated with these implants and other medical devices rises [1].

To prevent implant-associated infections, one approach is to improve the antimicrobial properties using antibacterial coatings [2]. For this, one way is to create a permanently effective, non-leaching and immobilised antimicrobial compound on the surface that prevents the attachment of bacteria or kills them on contact [3].

Another attempt is the controlled release of an antibiotic from a coated surface [4] suffering primarily from providing perfect conditions for resistance development for bacteria. Coating of titanium implant material with antiseptics [5,6], essential oils [7], antimicrobial peptides [8], and effective silver or copper ion implantation [9,10] may be good alternatives reducing the risk of drug resistance…

Consensus on Wound Antisepsis: Update 2018

Wound antisepsis has undergone a renaissance due to the introduction of highly effective wound-compatible antimicrobial agents and the spread of multidrug-resistant organisms (MDROs). However, a strict indication must be set for the application of these agents.

An infected or critically colonized wound must be treated antiseptically. In addition, systemic antibiotic therapy is required in case the infection spreads. If applied preventively, the Wounds-at-Risk Score allows an assessment of the risk for infection and thus appropriateness of the indication. The content of this updated consensus recommendation still largely consists of discussing properties of octenidine dihydrochloride (OCT), polihexanide, and iodophores.

The evaluations of hypochlorite, taurolidine, and silver ions have been updated. For critically colonized and infected chronic wounds as well as for burns, polihexanide is classified as the active agent of choice…

Review on the Efficacy, Safety and Clinical Applications of Polihexanide, a Modern Wound Antiseptic

Infected wounds are still one of the great challenges in med-
icine. In the last decade, it has become increasingly clear that antimicrobial chemotherapy is limited by the spread of antimicrobial resistance. Fortunately, new, highly effective antiseptic substances with a broad antimicrobial spectrum are available, so local treatment is expected to get increasingly more important in wound therapy.

This paper reviews the antiseptic agent polihexanide (polyhexamethylene biguanide, PHMB), one of the most promising substances available today, from a clinical point of view, focusing on efficacy, safety and clinical applications…

Effect of antiseptic irrigation on infection rates of traumatic soft tissue wounds: a longitudinal cohort study

Acute traumatic wounds are contaminated with bacteria and therefore an infection risk. Antiseptic wound irrigation before surgical intervention is routinely performed for contamined wounds. However, a broad variety of different irrigation solutions are in use. 

The aim of this retrospective, non-randomised, controlled longitudinal cohot study was to assess the preventive effect of four different irrigation solutions before surgical treatment, on wound infection in traumatic soft tissue wounds.

The large patient numbers in this study demonstrated a robust superiority of 0.04% PHMB to prevent infection in traumatic soft tissue wounds. These retrospective results may further provide important information as the basis for power calculations for the urgently needed prospective clinical trials in the evolving field of wound antisepsis…